The Victor Valley is situated approximately 97 miles northeast of Los Angeles and 35 miles northeast of San Bernardino, just north of the San Bernardino Mountains, at the edge of the Mojave Desert. Interstate 15 and State Highway 18 intersect near the center of Victorville and the city is bordered on the west by Highway 95. Major trucking and rail routes run through the area and Victorville is about 40 minutes drive from Ontario Airport, which offers passenger and commercial air cargo service to major U.S. cities and overseas.

Residents and businesses are served by an integrated fixed route transit system that provides transportation options between communities and the greater region. Victor Valley Transit offers curb to curb bus service throughout Victorville and other High Desert communities and Greyhound provides scheduled bus service to and from the area. Amtrak provides commuter rail service to and from Victor Valley. Freight train service is provided by the Atchison, Topeka & Santa Fe and Union Pacific railway companies.

Three airports are located in the Victor Valley itself, including airport facilities in Apple Valley and Hesperia and Southern California Logistics Airport (formerly George Air Force Base) is located in the City of Victorville and offers business air cargo facilities.

Within a 50 mile radius, via use of Interstate 15 (I-15), Victorville provides immediate access to all major interstates and highways that facilitate the Southern California market.

I-40 East/West providing access to Arizona
I-215 North/South providing access to Riverside County and San Diego County
I-10 East/West providing access to Orange County, Los Angeles County, Riverside County and Arizona
I-60 East/West providing access to Orange County, Los Angeles County, Riverside County and Arizona
I-91 North/South providing access to Corona, Riverside County and Orange County
Hwy. 58 Access to Central California
Hwy. 18 East/West providing access to North Los Angeles
Hwy. 395 North/South providing access to Reno